You may remember my trip to the 17th Age Management Conference this year and I was blown away with the ground breaking research, studies and results. I wanted to share this review for you to read when you have a moment it is truly fascinating.
A Review of the 17th Age Management Medicine Conference
Ron Shane, N.D., Ph.D., OMD, MFA, and Karan Pandher
Many of the speakers, such as Florence Comite, M.D. of New York City and Sangeeta Pati, M.D. of Orlando, expanded the paradigm concerning the focus of this conference to include optimizing lifestyle strategies. These medical clinicians asserted that the most propitious medical strategy for healing a patient is lifestyle mediated protocols. Dr. Pati purported that clinicians must go beyond normalizing bodily homeostasis, and educate patients to optimize all dimensions of the body’s physiology.
Dr. Pati stated that she is not satisfied with her patients losing weight, mitigating their fasting glucose, reducing anxiety and depression. She encourages all her patients to adapt a lifestyle in which to develop the furtive aspects of self. In her view, being a medical clinician must connote more than treating a patient’s ostensible malaises; and it should actually be more oriented to educating them how to integrate all dimensions of their physical gestalt in order to achieve enhanced actualization. Most of the speakers at this conference concur that the paradigm of only treating flagrant symptoms is no longer sufficient for clinical medicine.
It was discerned by many speakers that the pharmaceutical industry cannot medically treat the aberrant epigenetics of our current lifestyle mediated health epidemic. Dr. Pati is able to psychologically motivate her patients to adhere to lifestyle protocols, rather than be inundated with problematic drug therapies to medicinally improve their debilitating symptologies. Many of the lecturers emphasize that an ostensible manifestation of a succinct disease represents a patient and the medical community’s failure to manage overall lifestyle. Dr. Pati introduced the concept of body and mind integration as a way to efficaciously improve a patient’s health status.
Alan Wu, M.D. gave an intriguing lecture on the relationship between gut bacteria flora and the body’s immune system. Several other speakers such as Barry Sears, Ph.D. and Dr. Shane alluded to the fact that the human organism is primarily comprised of bacterial cells rather than human eukaryotic cells. According to Dr. Wu and Dr. Sears, there must be a synergy or efficacious relationship between the body’s immune system and predominant gut flora. Dr. Wu emphasized that there should be a harmony and sacred relationship between the body’s eukaryotic cells and the millions of bacteria flora.
It appears that eukaryotic cells may actually be under the influence or servitude of bacteria cells. Western medicine is realizing that the etiology of many diseases are based on the dysregulation of bacterial colonization and their aberrant cellular dynamics. There is increasing evidence as alluded to by Dr. Wu that rheumatoid arthritis is engendered by a kind of pathogenesis in the relationship between gut flora and the over amplification of the body’s immune response.
A recent conference on gastrointestinal pathogenesis held earlier this year at UCSD substantiated Dr. Wu’s sentiments regarding that many pathologies of the gut are related not only to the up regulation of certain bacteria colonies, but more importantly, in toxic paracrine factors secreted by bacterial cells as the homeostatic structure of their colonization is impacted by the dysregulatory molecular events of many bodily organ systems. Many other speakers at this conference implicitly stated that the etiology of many pathologies are related to perturbations in cytokine activity, which may be induced by the over colonization of certain bacterial flora.
Some medical biologists are now asserting that the epigenetics of our trillion bacteria cells may modulate not only our behavior, but likewise our overall general health status. The synergistic behavior of bacterial colonies represent a particular level of evolution prior to the aggregation of eukaryotic cells, which are a more complex arrangement of DNA nucleotides that may be contingent on bacterial cellular dynamics. Thus, the arrangement of many divergent strains of bacterial colonies is an initial stage in the evolution towards multiple cellular organisms.
Medical biologists like Dr. Wu comprehend that the complex multiple cellular organisms like mammals can be considered as scaffolds for the structural dynamics of many kinds of bacterial strains. In general, mammals have evolved like other multiple cellular systems on the structural organization of bacteria where they are the implicit matrix of eukaryotic cellular organization. The epigenetics of our complex flora is an important factor for determining our health status as well as many eukaryotic molecular dynamics.
Dennis Lox, M.D. presented anecdotal evidence that the utilization of stromal vasculature fraction derived from adipose tissue can mitigate chronic cytokine inflammatory pathogenesis in many human phenotypes. He demonstrated in certain patients that there was some degree of hyaline cartilage genesis as a function of certain regenerative therapies. Dr. Lox pointed out that there is not any evidence that progenitor cells from the stromal vasculature fraction actually induces protein expression which is necessary for the development of cartilage. Many cells responsible for these secretions of the multitude of proteins, which compromise cartilage are down regulated when there is an overexpression of inflammatory cytokines like interleukin 1, 6, 8, and TNF alpha.
Dr. Shane discussed non-pharmacological strategies to reduce systemic inflammation. Jonathan S. Wilensky, M.D. and Dr. Shane stated that the reduction of visceral fat, which expresses a diverse array of inflammatory proteins is responsible for a bevy of pathologies including cardiovascular disease as well as type 2 diabetes. The contemporary human is the only mammalian phenotype which has an excessive degree of visceral adiposity. These speakers purported that obesity is not an aesthetic issue, but rather an invidious pathophysiological syndrome.
Type 2 diabetes, cardiovascular disease, syndrome X, autoimmune pathologies, Alzheimer’s, and accelerated aging are escalated as a function of visceral adiposity. Fatty liver disease, which engenders hepatic cirrhosis, is similar to chronic alcoholism in terms of its destruction of hepatic cells. Dr. Shane asserted that food addiction induces a similar mesolimbic dysregulation to opiates with respect to actions of the MU receptor and dopanergic neurons. Obesity must now be viewed as a problematic addiction, which is impacting the majority of Americans. Clinicians are now becoming privy to the fact that obesity is a neuroendocrine pathology, and is similar to other virulent addictions. Losing weight is as difficult as forsaking opiates, cigarettes, alcohol, or cocaine.
Some medical theorists are suggesting that visceral obesity is far more catastrophic to the body’s physiology as compared to other addictions. Neuroendocrinologists like George Koob, Ph.D. have demonstrated that when the mammalian organism becomes addicted to fat, sugar, opiates, cocaine, and alcohol that this phenomenon causes changes in receptor concentration as well as an activation of certain molecular pathways which induces the activation of super circuits that are extremely difficult to down regulate through conscious intervention. Many speakers at this conference stated that they were successful with emphatic intervention to work with their patients on food addiction.
Some of the speakers who were involved in the session on inflammation stated that processed foods as well as consumption of processes with high concentration of simple sugars induced the secretion of inflammatory interleukins. Drs. Sears, Wu and Shane all asserted that food agents, which are commercially altered, change the homeostasis of the gut flora in the gastrointestinal system. Certain problematic gut flora are causing the pathophysiological up regulation of inflammatory cytokines and affecting the cellular homeostasis of the immune system. The speakers in the inflammation track all agreed that it is just as important to change the kinds of food that are being ingested as it is to reduce caloric intake.
Dr. Sears discussed the issue of the glycosylation of proteins and how this biochemical phenomenon alters the binding affinity and molecular structures of these cytokines. This problematic phenomenon may cause the activation of certain receptors that over express proteins which are responsible for tissue regeneration. Many lecturers at this meeting discussed how exercise engenders proteins, which are not only anti-inflammatory; but more importantly are trophic and enzymatic agents that are responsible for the salubriousness of the human entity’s homeostatic functionality. All mammals have evolved to be active throughout their waking status and only humans are chronically sedentary. This epigenetic virulent scenario is negatively impacting the brain’s physiology as well as the metabolism and efficacy of the muscle skeletal system.
The lectures at this conference varied in terms of their viewpoint on what constitutes a healthy exercise regime. A certain speaker stated that there are tremendous benefits from 20 minutes of vigorous walking a day whereas others purported that humans need at least 90 minutes of robust activity including running, weight lifting, as well as mind and body exercises in order to reduce systemic inflammation, and to optimize neurological and muscular functionality. All the speakers agreed that the contemporary human must find strategies to mitigate their perceived stress and anxiety.
Dipnarine Maharaj, MB.ChB, M.D. lectured on regenerative medicine; and his focus was primarily on how the up regulation of chronic diseases is a function of the mitigation of progenitor cell activity and senescence. Many of the other speakers reiterated that aging can be considered as a problematic up and down regulation of thousands of genes resulting in the elimination of necessary trophic and enzymatic factors required for bodily salubriousness. Dr. Maharaj stated that the variegated array of stem cells in the body consistent with the older phenotype are not secreting the necessary cytokines to propitiously stimulate the innate and adaptive immune system in order to mitigate chronic deleterious pathologies.
Dr. Maharaj asserted that he is able to extract stem cells from the blood, and then employ certain cytokines invitro to ameliorate their translational protein expression profile. He has observed that these diverse array of stem cells now become more efficacious in their response to mitigating cellular tumor genesis. This hematologist believes that protocols must be developed to enhance the proclivities of the body’s stem cells in order to mollify the likelihood of abating chronic diseases. Furthermore, many age related pathologies can be alleviated by optimizing stem cells’ transcriptional activities.
Dr. Maharaj is working on utilizing a novel peptide matrix for the older phenotype to mollify cellular senescence. There is some indication that autologous stem cell transplantation in the older phenotype when treating cancers or osteoarthritis that these high concentrations of progenitor cells must be optimized by a peptide matrix prior to reinjecting them back into the human phenotype. He argued that enhancing the biological prowess of autologous stem cells is necessary in the older phenotype to treat various kinds of neoplasia as well as joint related arthritis. In general, biodentical hormone replacement to a certain degree changes the protein profile in many cell lines in the older phenotype.
Mark Gordon, M.D. emphasized the benefits of exogenous growth hormone replacement therapy in clinically deficient adults. He stated that GH and IGF-1 receptors are ubiquitous throughout the body, and affect the translation of a wide range of protein and enzymatic factors, which are necessary for optimal homeostasis as humans age. GH and IGF-1 down regulation is responsible for bone and muscle tissue dysregulation; and most likely, impacts negatively the efficacy of stem cells as well as their protein translation. GH exogenous therapy in a deficient adult has neurophysiological protective effects on neuron functionality as well as improves cognitive performance. GH therapy in a clinically deficient adult can enhance the body’s physiological dynamics from that of cognitive functionality to the translational activities of many kinds of progenitor cells.
This conference was intriguing where the lectures provided medical clinicians with a wide range of protocols to optimize a patient’s health status. Dr. Wu lectured on the molecular machinations of epigenetics. His fascinating discussion explained how methylation at a gene’s promoter site can cease the transcription of a particular mRNA. Epigenetics or particular facets of the environmental milieu can not only prevent the transcription of a gene, but likewise keep it unavailable as it is wrapped around a histone. The succinct aspects of the environmental milieu produces translational modification in gene transcription in a diverse array of cell lines.
Ron Shane, Ph.D., O.M.D., N.D., is a 7th degree I.T.F. Tae Kwon Do black belt and is currently a research scholar at U.C. San Diego, working in the field of neuroendocrinology and optimal physiology. Contact Dr. Shane at [email protected] or [email protected].